VIP: Side Effects & Safety

Part of the VIP Complete Guide

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Overall Safety Profile

VIP is an endogenous neuropeptide, providing inherent biological compatibility. However, its potent vasodilatory effects require monitoring, particularly in patients with low blood pressure. Side effects are generally manageable and dose-dependent.

Reported Side Effects

  • Nasal congestion: Common with intranasal use
  • Diarrhea: VIP stimulates intestinal secretion
  • Hypotension: Vasodilation can lower blood pressure
  • Flushing: Related to vasodilatory effects
  • Headache: Occasionally reported

Important Limitations

VIP is not FDA-approved for any indication and is available only through compounding pharmacies. Quality and concentration can vary between sources. The extremely short half-life requires frequent dosing, limiting practical utility. Long-term safety data from controlled trials is limited.

Contraindications

  • Hypotension or cardiovascular instability
  • Active diarrheal illness
  • Pregnancy and breastfeeding
  • Known hypersensitivity to VIP

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.