VIP: Benefits & Research
Part of the VIP Complete Guide
Research Peptides
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Anti-Inflammatory & Immunomodulatory
VIP shifts immune responses from Th1 (pro-inflammatory) toward Th2 (anti-inflammatory), generates regulatory T cells, and modulates dendritic cell function. Research demonstrates efficacy in animal models of rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease.
CIRS Protocol Application
VIP is used as the final step in the Shoemaker protocol for chronic inflammatory response syndrome. After completing preceding steps (cholestyramine, VCS correction, MARCoNS treatment, etc.), intranasal VIP is used to normalize residual biomarker abnormalities including low MSH, elevated TGF-β1, and MMP-9.
Neuroprotective Effects
VIP promotes neuronal survival, stimulates neurite outgrowth, and modulates glial cell function. Research shows neuroprotective effects in models of Parkinson's disease, Alzheimer's disease, and cerebral ischemia through VPAC1/VPAC2 receptor activation.