Sermorelin: Side Effects & Safety

Part of the Sermorelin Complete Guide

Partner

Research Peptides

BioLongevity Labs15% Off
Shop Peptides at BioLongevity Labs

We may earn a commission if you purchase through this link, at no extra cost to you.

Common Side Effects

  • Injection site reactions (16%): Pain, redness, or swelling — most common
  • Facial flushing (4%): Transient, particularly with initial doses
  • Headache (3%): Mild and transient
  • Dizziness (2%): Typically with first administrations
  • Mild water retention: Less pronounced than with exogenous GH

Natural feedback loops prevent excessive GH elevation, reducing risk of carpal tunnel syndrome, joint pain, and insulin resistance seen with exogenous GH.

Contraindications

  • Active malignancy (GH may promote tumor growth)
  • Pituitary tumors
  • Non-functional pituitary — sermorelin requires intact pituitary to work
  • Hypersensitivity to GHRH

For the complete overview, see the sermorelin complete guide.

Researching peptides? We did the hard part.

Get our free Peptide Starter Kit — the 5 most researched compounds, simplified into one actionable guide.

Related Guides

Peptides for Weight Loss

Research-backed peptides studied for fat loss and metabolic support.

Peptides for Muscle Growth

Compounds researched for lean mass, recovery, and performance.

Peptides for Healing

Peptides studied for tissue repair, injury recovery, and regeneration.

How to Reconstitute Peptides

Step-by-step guide to safely mixing lyophilized peptides with BAC water.

How to Inject Peptides

Subcutaneous injection technique, site rotation, and sterile handling.

Peptide Reconstitution Calculator

Calculate exact BAC water volumes and dosing for any peptide vial.

PI

Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.