Sermorelin: Dosage & Administration
Part of the Sermorelin Complete Guide
Research Peptides
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Sermorelin Dosage Protocols
| Application | Dose | Route | Timing |
|---|---|---|---|
| Anti-aging / GH optimization | 200–300 mcg | Subcutaneous | Before bedtime |
| Body composition | 200–500 mcg | Subcutaneous | Bedtime or post-exercise |
Bedtime administration is preferred because it coincides with the natural nocturnal GH pulse during deep sleep (Stage 3/4 NREM). Some protocols include a second injection post-exercise to synergize with exercise-induced GH release.
Fasted Administration
Sermorelin should be taken on an empty stomach — at least 2 hours after eating. Elevated blood glucose and insulin suppress GH release from the pituitary and blunt sermorelin's effectiveness. This is a critical practical consideration.
Reconstitution
Reconstitute with bacteriostatic water. Use the peptide calculator for volumes. See the reconstitution guide for step-by-step instructions.
Cycle Length
Research protocols commonly run 3–6 months. IGF-1 levels typically stabilize within 2–4 weeks. Body composition changes are usually noticeable at 4–12 weeks. Some protocols use continuous treatment, as sermorelin maintains natural feedback loops and does not suppress endogenous GH production.