Sermorelin: Benefits & Research
Part of the Sermorelin Complete Guide
Research Peptides
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Growth Hormone Optimization
Sermorelin restores youthful GH levels by stimulating the pituitary's natural pulsatile release pattern, preserving IGF-1 feedback loops. Key advantages over exogenous GH:
- Maintains natural pulsatile GH secretion
- Preserves negative feedback (somatostatin regulation prevents excess)
- Lower risk of GH-related side effects (fluid retention, insulin resistance)
- Pituitary does not atrophy as with exogenous GH replacement
Body Composition
Clinical studies showed decreased visceral fat, increased lean mass, and improved exercise capacity over 12 weeks. GH's lipolytic and anabolic properties drive these effects.
Sleep Quality
Sermorelin before bedtime enhances deep sleep (slow-wave sleep), creating a positive feedback loop — GH is released during deep sleep, and sermorelin increases deep sleep duration.
Anti-Aging Applications
GH declines ~14% per decade after age 30. By 60, most adults produce only 20–25% of their age-25 levels. Sermorelin-based GH restoration is associated with improved skin thickness, immune function, energy, and recovery. For comparison with tesamorelin, see the compound hub page.