Pinealon: Complete Guide
Pinealon is a synthetic tripeptide (Glu-Asp-Arg) developed by the Khavinson group at the Saint Petersburg Institute of Bioregulation and Gerontology. It belongs to the class of Khavinson bioregulatory peptides — short peptides designed to regulate gene expression in specific tissues. Pinealon is researched for neuroprotective effects, pineal gland function support, and cognitive enhancement, with particular interest in its ability to cross the blood-brain barrier due to its small size.
Last updated: 2026-01-29
Quick Facts
- Category
- nootropic
- Also Known As
- EDR peptide
- Related Goals
- cognitive enhancement, sleep
Who Researches Pinealon?
Pinealon is researched by people interested in cognitive support and neuroprotection through bioregulatory peptides. It's part of the Khavinson school of peptide bioregulation — if you're exploring short peptides like Epitalon (a related Khavinson peptide for telomerase activation), Pinealon targets the brain specifically. Those interested in pineal gland health, sleep regulation, and neuroprotective strategies for aging will find it relevant, though the evidence base is primarily from Russian research groups.
Research Peptides
We may earn a commission if you purchase through this link, at no extra cost to you.
What Is Pinealon?
Pinealon was developed by Professor Vladimir Khavinson as part of a systematic program to create tissue-specific bioregulatory peptides. The Khavinson group hypothesizes that short peptides (2-4 amino acids) can interact with specific DNA sequences to regulate gene expression in target tissues — a concept they term 'peptide bioregulation.'
Pinealon was designed to target the pineal gland and central nervous system. The pineal gland produces melatonin and other neuromodulators that regulate circadian rhythm, antioxidant defense, and neuroprotection. Research suggests Pinealon may support these functions by modulating gene expression in pinealocytes and neurons.
Mechanism of Action
Proposed mechanisms from published research (primarily from Russian academic groups):
- Gene expression modulation: Khavinson's research suggests tripeptides can interact with DNA and histone proteins to modulate gene expression — in Pinealon's case, targeting neuroprotective gene programs
- Antioxidant support: Cell culture studies showed Pinealon reduced reactive oxygen species (ROS) in neuronal cells under oxidative stress
- Anti-apoptotic effects: Protected neurons from programmed cell death in models of neurodegeneration
- Melatonin regulation: May support melatonin synthesis in the pineal gland, though direct evidence is limited
Researching peptides? We did the hard part.
Get our free Peptide Starter Kit — the 5 most researched compounds, simplified into one actionable guide.
Dosage Overview
Published research protocols typically use Pinealon at 10–100 mcg doses administered subcutaneously or intranasally. Some oral capsule formulations are available in Russian markets. Standard peptide reconstitution applies for injectable forms.
Use the peptide calculator for reconstitution volumes.
Side Effects & Safety
- Limited safety data: Most research comes from in vitro studies and small Russian clinical studies
- Generally well-tolerated: Published studies report no significant adverse effects
- Injection site reactions: Mild and transient with subcutaneous use
- No known drug interactions: However, comprehensive interaction studies have not been performed