Pinealon: Benefits & Research

Cell culture studies demonstrate Pinealon protects neurons from oxidative stress-induced damage by reducing reactive oxygen species (ROS) and preventing apoptosis. The tripeptide (Glu-Asp-Arg) crosses the blood-brain barrier due to its small size, enabling direct CNS activity.

Pinealon is hypothesized to support melatonin synthesis and pineal gland function, though direct evidence for this mechanism is limited. The pineal gland's function declines with age (calcification), and Pinealon is researched as part of Khavinson's bioregulatory approach to supporting age-related organ decline.

Animal studies suggest Pinealon improves cognitive function in models of neurodegeneration and age-related cognitive decline. The proposed mechanism involves regulation of gene expression in neural tissue through peptide-DNA interactions described in the Khavinson bioregulation theory.