Epitalon: Complete Guide
Epitalon (also spelled epithalon or epithalone) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. It is based on the natural peptide epithalamin, which is produced by the pineal gland. Epitalon's primary research interest centers on its ability to activate telomerase — the enzyme that maintains telomere length — making it one of the most studied peptides in longevity and anti-aging research.
Last updated: 2026-01-28
Quick Facts
- Category
- therapeutic
- Also Known As
- Epithalon, Epithalone
- Related Goals
- anti aging
Who Researches Epitalon?
Epitalon is researched by people specifically interested in longevity and anti-aging at the most fundamental level — telomere maintenance. If you believe cellular aging starts with telomere shortening (and the research supports this), epitalon is one of the few compounds that directly activates telomerase. It appeals to longevity-focused individuals, biohackers, and people building comprehensive anti-aging protocols. Its short cycle length (10–20 days, a few times per year) makes it one of the easiest peptides to incorporate. Often stacked with NAD+ and SS-31 for multi-pathway anti-aging coverage.
Related Resources
- Stacks: Anti-Aging Stack
- Comparisons: Epitalon vs FOXO4-DRI
Research Peptides
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What Is Epitalon?
Epitalon was developed through decades of research into pineal gland peptides and their role in aging. Professor Khavinson's work demonstrated that the pineal gland produces regulatory peptides that decline with age, and that supplementing these peptides could restore youthful function in aging organisms.
The most significant finding was epitalon's ability to reactivate telomerase in somatic cells. Telomeres — the protective caps at the ends of chromosomes — shorten with each cell division, eventually triggering cellular senescence (aging) when they become critically short. Telomerase is the enzyme that can rebuild telomeres, but it is silenced in most adult cells. Epitalon's ability to reactivate this enzyme has made it a centerpiece of anti-aging peptide research.
Mechanism of Action
- Telomerase activation: Induces expression of the telomerase catalytic subunit (hTERT), reactivating telomere maintenance in somatic cells
- Telomere elongation: Studies showed increased telomere length in human cell cultures treated with epitalon
- Melatonin regulation: Restores normal melatonin production by the pineal gland, which declines significantly with age
- Circadian normalization: Through melatonin effects, helps normalize sleep-wake cycles disrupted by aging
- Antioxidant gene expression: Upregulates endogenous antioxidant enzymes
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Dosage Overview
| Parameter | Detail |
|---|---|
| Dose | 5–10 mg daily |
| Route | Subcutaneous or intramuscular |
| Cycle | 10–20 day course |
| Frequency | 2–3 courses per year |
Epitalon is typically used in short, periodic courses rather than continuously. Use the peptide calculator for reconstitution.
Side Effects & Safety
- Injection site reactions: Mild redness
- Generally well-tolerated in published animal and limited human studies
- No tumor promotion: Despite activating telomerase (which is active in cancer cells), studies showed epitalon actually reduced spontaneous tumor incidence in aging animals
- Limited human data: Most evidence comes from Russian research with limited Western clinical validation