MOTS-c: Dosage & Administration

MOTS-c dosing in research follows a relatively straightforward protocol compared to multi-phase peptides:

Protocol	Dose	Frequency	Duration
Standard	5–10 mg	3–5× weekly	4–8 weeks
Exercise-focused	5–10 mg	Pre-exercise days	8–12 weeks

MOTS-c doses are notably higher than many peptides due to its nature as a mitochondrial-derived signaling peptide rather than a receptor agonist. The peptide mimics exercise-induced metabolic signaling, activating AMPK and improving glucose uptake independently of insulin.

MOTS-c typically comes in 5mg or 10mg lyophilized vials:

• 10mg vial + 2mL BAC water = 5mg/mL — draw 1mL for a 5mg dose
• 5mg vial + 1mL BAC water = 5mg/mL — draw 1mL for a 5mg dose

Use the peptide calculator for exact volumes. See the reconstitution guide for preparation steps.

MOTS-c timing considerations:

• Exercise timing: Some protocols administer MOTS-c 30–60 minutes before exercise to potentiate the exercise-mimetic effect
• Non-exercise days: Morning administration is commonly used
• Cycle length: 4–8 weeks is standard, with some metabolic research protocols extending to 12 weeks
• Fasting: No strict fasting requirement, though some protocols prefer fasted administration for metabolic research

Standard peptide storage:

• Lyophilized: -20°C long-term, 2–8°C for months
• Reconstituted: Refrigerate at 2–8°C, use within 28 days
• Protect from light and avoid freeze-thaw cycles

See the peptide storage guide for complete guidelines.