Kisspeptin: Side Effects & Safety

Part of the Kisspeptin Complete Guide

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Overall Safety Profile

Kisspeptin has demonstrated a favorable safety profile in clinical studies, with no serious drug-related adverse events reported. As an endogenous neuropeptide, it benefits from biological compatibility. Its short half-life limits sustained exposure.

Reported Side Effects

  • Injection site reactions: Mild, transient
  • Transient hormonal changes: LH and testosterone increases are short-lived and dose-dependent
  • No OHSS cases: A key safety advantage in IVF applications compared to hCG

Important Limitations

Continuous kisspeptin exposure desensitizes GnRH neurons, paradoxically suppressing reproductive hormones — pulsatile administration is essential. Long-term safety data is limited. The effects of chronic kisspeptin administration on reproductive function, bone density, and metabolic health require further study.

Potential Contraindications

  • Hormone-sensitive cancers (breast, prostate)
  • Precocious puberty
  • Pregnancy (effects on pregnancy maintenance unknown)

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.