Kisspeptin: Benefits & Research

Part of the Kisspeptin Complete Guide

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Fertility & IVF Applications

Kisspeptin can trigger oocyte maturation in IVF protocols with significantly lower risk of ovarian hyperstimulation syndrome (OHSS) compared to hCG. Studies by Abbara et al. demonstrated successful oocyte maturation and pregnancy in high-risk patients, with no cases of clinically significant OHSS.

HPG Axis Regulation

As the master upstream regulator of GnRH, kisspeptin controls the entire reproductive hormone cascade. Research demonstrates it can stimulate LH, FSH, and testosterone production in both men and women — with potential applications in hypogonadism, delayed puberty, and hypothalamic amenorrhea.

Sexual Function & Desire

Beyond reproductive hormones, kisspeptin activates limbic brain circuits involved in sexual arousal and attraction. fMRI studies show kisspeptin enhances brain responses to sexual and romantic stimuli, suggesting direct effects on sexual desire independent of testosterone elevation.

Frequently Asked Questions

References

  1. Abbara A, et al.. Efficacy of kisspeptin-54 to trigger oocyte maturation in women at high risk of OHSS. J Clin Endocrinol Metab, 2015.

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.