Kisspeptin: Dosage & Administration
Part of the Kisspeptin Complete Guide
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Dosage Protocols
| Form | Dose | Route | Application |
|---|---|---|---|
| Kisspeptin-54 | 1–6.4 nmol/kg | IV or SC | Clinical research |
| Kisspeptin-10 | 0.1–1 mcg/kg | IV or SC | Acute stimulation studies |
| IVF trigger | 9.6 nmol/kg | SC | Oocyte maturation |
Preparation
Kisspeptin is reconstituted from lyophilized powder with sterile water or bacteriostatic water. Use the peptide calculator for precise reconstitution volumes. Clinical research preparations undergo additional quality testing.
Timing & Administration
Pulsatile administration is critical — continuous kisspeptin exposure desensitizes GnRH neurons and paradoxically suppresses reproductive hormones. Clinical studies use single bolus or short-term infusion protocols. For IVF, kisspeptin is given as a single SC injection to trigger oocyte maturation.
Storage
- Lyophilized: -20°C for long-term storage
- Reconstituted: 2–8°C, use within 24 hours for clinical applications
- Protect from light and repeated freeze-thaw