Humanin: Benefits & Research
Part of the Humanin Complete Guide
Research Peptides
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Neuroprotection
Humanin was discovered as a survival factor against Alzheimer's-related amyloid-beta toxicity. It protects neurons from multiple insults including amyloid-beta, serum deprivation, and excitotoxicity. The HNG analog demonstrated neuroprotection in animal models of Alzheimer's disease, reducing cognitive decline and amyloid pathology.
Broad Cytoprotective Effects
Beyond neurons, humanin protects diverse cell types from apoptosis through BAX inhibition, STAT3 activation, and FPRL receptor signaling. Research shows protective effects in cardiac ischemia, hepatic injury, and renal damage models — suggesting a general cellular stress response role.
Metabolic Regulation
Humanin improves insulin sensitivity and glucose homeostasis in animal models. It interacts with IGFBP-3 to modulate IGF-1 signaling. Circulating humanin levels decline with age, and this decline correlates with metabolic dysfunction — suggesting humanin may play a role in age-related metabolic disease.