Gonadorelin: Side Effects & Safety

Part of the Gonadorelin Complete Guide

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Overall Safety Profile

Gonadorelin is identical to endogenous GnRH, providing excellent biological compatibility. It is FDA-approved as a diagnostic agent (Factrel) with a well-established safety profile for acute use. Side effects with pulsatile subcutaneous use are minimal.

Reported Side Effects

  • Injection site reactions: Mild and transient
  • Headache: Occasionally reported
  • Flushing: Transient
  • Nausea: Rare

Important Limitations

Critical: Continuous (non-pulsatile) administration desensitizes GnRH receptors and paradoxically suppresses LH/FSH — the opposite of the intended effect. Proper dosing intervals (not continuous infusion) are essential. Long-term safety data for off-label HPG axis maintenance during TRT is limited.

Contraindications

  • Hormone-dependent cancers (prostate, breast)
  • Pregnancy (may affect pregnancy maintenance)
  • Known hypersensitivity to GnRH or analogs

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.