Gonadorelin: Benefits & Research

Part of the Gonadorelin Complete Guide

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HPG Axis Maintenance During TRT

Exogenous testosterone suppresses LH and FSH to near-zero, causing testicular atrophy and infertility. Gonadorelin maintains pulsatile GnRH stimulation of the pituitary, preserving LH/FSH secretion and testicular function. This allows men on TRT to maintain sperm production and testicular volume.

Fertility Preservation

By maintaining FSH levels, gonadorelin supports spermatogenesis during testosterone therapy. This is critical for men who want to preserve future fertility while receiving TRT. It serves as an alternative to hCG for this purpose.

Diagnostic Applications

As FDA-approved Factrel, gonadorelin is used to evaluate pituitary gonadotroph function. A 100 mcg IV dose followed by LH/FSH measurement at 15 and 30 minutes distinguishes pituitary from hypothalamic causes of hypogonadism.

Frequently Asked Questions

References

  1. Belchetz PE, et al.. Hypophysial responses to continuous and intermittent delivery of GnRH. Science, 1978.

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.