CJC-1295: Side Effects & Safety

CJC-1295 side effects are primarily related to the GH elevation it produces. The non-DAC form (Mod GRF 1-29) generally has a better side effect profile than the DAC version because it preserves pulsatile GH release rather than producing sustained elevation. Most side effects are dose-dependent and resolve with dose reduction.

• Water retention: GH-related fluid retention causing bloating, puffy hands/face — more pronounced with the DAC form
• Flushing/warmth: Transient warm sensation or facial flushing shortly after injection
• Numbness/tingling: Particularly in extremities, related to GH-mediated fluid effects on peripheral nerves
• Injection site reactions: Mild redness or irritation
• Increased hunger: GH secretagogues can increase appetite through indirect ghrelin pathway effects
• Headache: Occasionally reported, typically transient

CJC-1295 with DAC carries additional considerations due to sustained (non-pulsatile) GH elevation:

• GH receptor desensitization: Constant GH stimulation may reduce receptor sensitivity over time
• Insulin resistance: Sustained GH elevation antagonizes insulin action, potentially affecting glucose metabolism
• Joint pain: More common with sustained GH elevation than pulsatile release
• Carpal tunnel-like symptoms: Fluid retention affecting the carpal tunnel

These concerns are one reason the non-DAC form (Mod GRF 1-29) is generally preferred in research settings.

• Active cancer (GH and IGF-1 are growth-promoting)
• Diabetic retinopathy
• Pregnancy and breastfeeding
• Active acromegaly or pituitary disorders

Return to the CJC-1295 overview for general information.