CJC-1295: Benefits & Research

CJC-1295's primary benefit is sustained elevation of growth hormone levels. Clinical research demonstrated that a single dose of CJC-1295 with DAC increased mean GH levels by 2–10 fold and IGF-1 levels by 1.5–3 fold for 6–8 days. The non-DAC form produces acute GH pulses 2–3 fold above baseline, preserving the natural pulsatile secretion pattern.

This GH optimization occurs through the GHRH receptor, which is distinct from the ghrelin receptor targeted by ipamorelin. Combining CJC-1295 with ipamorelin activates both pathways simultaneously, producing synergistic GH release greater than either peptide alone.

Elevated GH and IGF-1 promote anabolic effects including increased muscle protein synthesis, enhanced nitrogen retention, and improved recovery from resistance training. GH also promotes lipolysis (fat breakdown), making CJC-1295 relevant to both muscle-building and fat-loss research. For other peptides in this space, see sermorelin and tesamorelin. For broader context, visit peptides for muscle growth.

The largest natural GH pulse occurs during deep (slow-wave) sleep. By amplifying this nocturnal pulse (when dosed at bedtime), CJC-1295 may improve sleep quality and overnight recovery. GH plays a central role in tissue repair, immune function, and cognitive consolidation during sleep.

GH secretion declines approximately 14% per decade after age 30 — a process termed somatopause. CJC-1295 aims to restore more youthful GH output. Research has associated GH optimization with improved skin quality, increased bone density, better cognitive function, and enhanced immune response — all of which decline with age. See the anti-aging peptides guide for related compounds.