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SLU-PP-332: Benefits & Research

Part of the SLU-PP-332 Complete Guide

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Endurance Enhancement

Sedentary mice treated with SLU-PP-332 showed 45–70% improvements in treadmill running endurance without any exercise training. This effect is mediated by ERRα/γ activation, which increases oxidative muscle fiber content and mitochondrial density — the same adaptations produced by endurance exercise.

Metabolic Effects

SLU-PP-332 increased mitochondrial biogenesis, enhanced fatty acid oxidation, and protected against diet-induced obesity in mice. Animals on high-fat diets gained significantly less weight when treated with SLU-PP-332, suggesting enhanced metabolic rate and fat utilization.

Muscle Fiber Type Switching

ERR activation shifted muscle fiber composition toward type I (slow-twitch, oxidative) fibers — the endurance fiber type. This mirrors the fiber type adaptation that occurs with prolonged endurance training and explains the improved exercise capacity.

Frequently Asked Questions

References

  1. Kim SH, et al.. ERR agonist SLU-PP-332 improves exercise capacity and prevents obesity. J Biol Chem, 2023.

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Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.