Semax: Benefits & Research

Part of the Semax Complete Guide

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Cognitive Enhancement

  • Enhanced spatial memory, associative learning, and novel object recognition in animal models
  • Human studies: improvements in attention, short-term memory, and cognitive flexibility
  • Significantly increases BDNF in the hippocampus — essential for synaptic plasticity
  • Increases NGF expression, supporting cholinergic neuron function for memory

Neuroprotective Effects

Approved in Russia for ischemic stroke. Activates neuronal survival pathways (PI3K/Akt, MAPK/ERK), reduces glutamate excitotoxicity, and suppresses apoptotic pathways. Clinical studies showed improved neurological outcomes when administered within 12 hours of ischemic stroke.

Mood and Motivation

Modulates serotonin and dopamine systems, contributing to improved drive and emotional well-being. Complementary to Selank, which focuses on anxiety reduction.

References

  1. Dolotov OV, et al.. Semax regulates BDNF and trkB expression in the rat hippocampus. Brain Research, 2006.

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.