OS-01: Benefits & Research

Part of the OS-01 Complete Guide

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Senescent Cell Clearance

OS-01 reduces senescence markers (p16INK4a, p21, SA-β-gal) in human skin equivalents. By clearing senescent "zombie cells," it reduces the senescence-associated secretory phenotype (SASP) — the cocktail of inflammatory factors that degrades collagen and accelerates aging in neighboring cells.

Epigenetic Age Reversal

OneSkin's published research reports OS-01 reduced the biological (epigenetic) age of skin samples as measured by DNA methylation clocks. The Horvath skin-blood clock showed reduced biological age in OS-01-treated samples compared to controls — a novel endpoint for skincare research.

Skin Barrier Function

Studies demonstrate improved skin barrier function and hydration in OS-01-treated human skin models. Healthier barrier function reduces transepidermal water loss and improves skin resilience against environmental stressors.

Frequently Asked Questions

References

  1. Zonari A, et al.. Senotherapeutic peptide treatment reduces biological age and senescence in human skin models. npj Aging, 2023.

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.