MGF: Side Effects & Safety

Part of the MGF Complete Guide

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Overall Safety Profile

MGF is an endogenously produced splice variant of IGF-1, providing inherent biological compatibility. Its local action profile limits systemic side effects compared to exogenous IGF-1 or growth hormone. However, human safety data is extremely limited.

Reported Side Effects

  • Injection site pain: Common with intramuscular injection, particularly into small muscle groups
  • Possible hypoglycemia: Through IGF-1 pathway activity, though less likely than with systemic IGF-1
  • Local swelling: At injection sites

Important Limitations

Most MGF research is preclinical. Human safety and efficacy data is essentially absent. Standard MGF's extremely short half-life raises practical challenges. The distinction between local and systemic effects of PEG-MGF is not well-characterized.

Potential Contraindications

  • Active cancer (growth factor activity)
  • Diabetes or hypoglycemia risk
  • Pregnancy and breastfeeding

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.