MGF: Benefits & Research

MGF's primary researched benefit is the activation and proliferation of satellite cells — muscle-specific stem cells that fuse with damaged fibers to promote repair and hypertrophy. Unlike mature IGF-1 which drives differentiation, MGF specifically activates the proliferation phase, expanding the pool of available repair cells.

MGF is produced endogenously in response to mechanical stress (exercise) and acts locally at the site of muscle damage. Research shows it promotes faster recovery from exercise-induced muscle damage and may enhance the adaptive response to resistance training.

MGF expression has been detected in brain tissue following ischemic injury, suggesting neuroprotective roles beyond muscle. Studies show MGF can protect neurons from apoptosis and promote neural stem cell proliferation, though this research is in early stages.