Hexarelin: Side Effects & Safety

Part of the Hexarelin Complete Guide

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Overall Safety Profile

Hexarelin is the least selective of the commonly used GHRPs, producing significant cortisol and prolactin elevations alongside GH release. The tendency toward receptor desensitization with continuous use further limits long-term utility compared to more selective alternatives.

Reported Side Effects

  • Cortisol elevation: Clinically significant — monitor with long-term use
  • Prolactin elevation: Can affect reproductive function and libido
  • Appetite stimulation: Ghrelin-mediated hunger
  • Desensitization: GH response diminishes after 4–8 weeks of continuous use
  • Flushing and warmth: Common immediately post-injection
  • Water retention: GH-mediated

Important Limitations

The cortisol and prolactin elevations are hexarelin's primary disadvantages versus ipamorelin. Chronic cortisol elevation can counteract anabolic benefits, promote fat storage, and impair immune function. Prolactin elevation may affect sexual function and mood. Desensitization necessitates cycling.

Potential Contraindications

  • Hyperprolactinemia or prolactin-sensitive conditions
  • Cushing's syndrome or conditions worsened by cortisol
  • Active cancer (GH is a growth factor)
  • Pregnancy and breastfeeding

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.