ARA-290: Side Effects & Safety

Part of the ARA-290 Complete Guide

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Overall Safety Profile

ARA-290 demonstrated a favorable safety profile in Phase 1 and Phase 2 clinical trials, with no serious drug-related adverse events. Crucially, it does not stimulate erythropoiesis — the primary safety concern with EPO-based therapeutics (blood thickening, thrombosis).

Reported Side Effects

  • Injection site reactions: Mild and transient
  • Headache: Occasionally reported
  • No erythropoietic effects: No increase in red blood cells, hematocrit, or thrombosis risk

Important Limitations

Clinical data is limited to Phase 1/2 trials with relatively small patient numbers. Long-term safety beyond 28-day treatment courses has not been characterized. ARA-290 is not yet approved for any indication.

Potential Contraindications

  • Known hypersensitivity to EPO-derived peptides
  • Pregnancy and breastfeeding (no safety data)

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.