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Reviewed against editorial standards · Updated 2026-01-29

ARA-290: Benefits & Research

Part of the ARA-290 Complete Guide

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Neuropathic Pain Relief

Phase 2 trials demonstrated ARA-290 improved neuropathic pain scores and increased small fiber nerve density in patients with sarcoidosis-associated neuropathy. Corneal confocal microscopy showed measurable nerve fiber regeneration — objective evidence of structural nerve repair.

Tissue-Protective Effects

ARA-290 activates the innate repair receptor (IRR), triggering anti-apoptotic and anti-inflammatory cascades. The IRR is expressed on stressed and damaged cells, making ARA-290's effects selectively targeted to injured tissue rather than healthy cells.

Metabolic Improvements

Studies in type 2 diabetes patients showed ARA-290 improved metabolic control alongside neuropathic symptom relief. The EPO-derived pathway has established connections to metabolic regulation beyond erythropoiesis.

FAQ

Frequently Asked Questions

References

  1. [1] Brines M, et al.. ARA 290 improves metabolic control and neuropathic symptoms in patients with type 2 diabetes. Mol Med, 2015.

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Austin Danner

Founder & Editor in Chief

Founder of Peptides Insider. Independent researcher focused on translating peer-reviewed peptide research into practical, evidence-based guides.

Reviewed against Peptides Insider editorial standards · Last reviewed 2026-01-29.