Tirzepatide: Side Effects & Safety

Part of the Tirzepatide Complete Guide

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Common Side Effects

  • Nausea (12–24%): Most common during titration, improves with continued use
  • Diarrhea (12–17%): Mild to moderate, most common during dose increases
  • Decreased appetite (5–11%)
  • Vomiting (5–9%)
  • Constipation (5–7%)
  • Abdominal pain (5–7%)
  • Injection site reactions (3–5%)

GI side effects are most common during the dose-escalation phase and typically diminish with continued treatment at a stable dose.

Serious Risks

  • Pancreatitis: Cases reported in trials. Discontinue if suspected.
  • Thyroid C-cell tumors: Boxed warning. GLP-1 agonists caused thyroid tumors in rodents. Contraindicated with personal/family history of medullary thyroid carcinoma or MEN2.
  • Gallbladder events: Increased cholelithiasis (gallstones) likely related to rapid weight loss.
  • Hypoglycemia: Low risk alone; increased with insulin or sulfonylureas.

For the complete overview, see the tirzepatide complete guide.

References

  1. Jastreboff AM, et al.. Tirzepatide once weekly for the treatment of obesity. NEJM, 2022.

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.