Tesofensine: Dosage & Administration

Part of the Tesofensine Complete Guide

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Dosage Protocols

DoseWeight Loss (24 wks)RouteFrequency
0.25 mg~6.7%Oral capsuleOnce daily
0.5 mg~10.6%Oral capsuleOnce daily
1.0 mg~12.8%Oral capsuleOnce daily

The 0.5 mg dose showed the best efficacy-safety balance in Phase 2 trials. The 1.0 mg dose produced greater weight loss but with more cardiovascular effects (heart rate, blood pressure).

Administration

Tesofensine is an oral capsule — no reconstitution or injection required. Taken once daily, typically in the morning to minimize insomnia risk from dopaminergic and noradrenergic activity.

Timing & Duration

Clinical trials administered tesofensine for 24 weeks. Morning dosing is preferred to reduce sleep disruption. Take with or without food. Long-term treatment data beyond 24 weeks is limited.

Storage

  • Store at room temperature in a dry location
  • Protect from moisture and excessive heat
  • Keep in original packaging

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.