Tesamorelin: Dosage & Administration
Part of the Tesamorelin Complete Guide
Tesamorelin (10mg)
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FDA-Approved Dosing
Tesamorelin has a well-defined dosing protocol established through its FDA approval:
| Parameter | Detail |
|---|---|
| Dose | 2 mg daily |
| Route | Subcutaneous injection |
| Site | Abdominal area, rotating injection sites |
| Timing | Once daily, at the same time each day |
| Assessment | Evaluate at 26 weeks; discontinue if no improvement in visceral fat |
The 2mg daily dose was determined through dose-ranging studies and confirmed in Phase 3 pivotal trials. Lower and higher doses were tested, with 2mg providing the optimal balance of efficacy and safety.
Reconstitution
In the commercial formulation (Egrifta SV), tesamorelin comes as a single-vial lyophilized powder reconstituted with 0.5 mL of provided sterile water for injection. The reconstituted solution should be used immediately.
For research-grade tesamorelin in different vial sizes, use the peptide calculator for reconstitution volumes. Follow the reconstitution guide for step-by-step instructions and the injection guide for subcutaneous technique.
Monitoring Requirements
The FDA labeling recommends monitoring during tesamorelin treatment:
- IGF-1 levels: Monitor periodically. Discontinue if IGF-1 levels become persistently elevated above the age-adjusted upper limit of normal
- Blood glucose: Monitor fasting glucose and HbA1c, particularly in patients with diabetes risk factors. Tesamorelin can impair glucose tolerance
- Visceral fat: Assess by CT or other imaging at 26 weeks. Discontinue if no meaningful reduction
- Hypersensitivity: Monitor for allergic reactions, particularly during initial administrations
Timing Considerations
Tesamorelin's label specifies once-daily injection without specific timing relative to meals. However, some clinicians recommend:
- Injecting at a consistent time each day to maintain stable GH stimulation
- Morning administration to align with the body's natural cortisol and GH rhythms
- Avoiding injection immediately after high-carbohydrate meals, as elevated blood glucose can blunt GH release
The half-life of tesamorelin is approximately 26 minutes, but the GH release it triggers lasts for several hours.