Retatrutide: Benefits & Research
Part of the Retatrutide Complete Guide
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Record Weight Loss
Retatrutide produced the highest weight loss ever recorded in a controlled anti-obesity trial:
| Dose | Mean Weight Loss | ≥20% Loss |
|---|---|---|
| 4 mg | -17.1% | 40% |
| 8 mg | -22.8% | 60% |
| 12 mg | -24.2% | 63% |
At 12mg, the weight loss curve had not plateaued at 48 weeks, suggesting even greater results with longer treatment. The triple mechanism — GLP-1 reducing appetite, GIP improving fat metabolism, glucagon increasing energy expenditure — attacks obesity from both intake and expenditure sides.
Liver Fat Reduction
A sub-study showed dramatic liver fat improvements:
- 82% mean relative reduction in liver fat at 8mg dose
- 86% of NAFLD patients achieved complete resolution (<5% liver fat)
- Results far exceed any current NAFLD treatment
Type 2 Diabetes
HbA1c reduction of -2.02% and body weight loss of -16.9% over 36 weeks at 12mg in T2D patients. See the peptides for weight loss guide for comparisons with tirzepatide.