LL-37: Dosage & Administration

LL-37 dosing in research:

Protocol	Dose	Frequency	Duration
Antimicrobial/immune	50–100 mcg	Once daily	2–4 weeks
Wound healing	50–100 mcg	Once daily	2–4 weeks

LL-37 is an endogenous antimicrobial peptide — the only human cathelicidin. It is naturally produced by epithelial cells, neutrophils, and macrophages in response to infection. Research doses are generally kept low relative to other peptides because LL-37 can be pro-inflammatory at higher concentrations.

LL-37 typically comes in 5mg vials:

• 5mg vial + 2.5mL BAC water = 2mg/mL (2,000 mcg/mL) — draw 0.05mL for 100 mcg
• 5mg vial + 5mL BAC water = 1mg/mL (1,000 mcg/mL) — draw 0.1mL for 100 mcg

Use the peptide calculator for precise volumes. See the reconstitution guide for preparation.

LL-37 timing considerations:

• Time of day: No strict timing requirement. Some protocols prefer morning dosing to align with immune activity patterns
• Cycle length: Short cycles of 2–4 weeks are typical. Extended use is generally avoided due to the pro-inflammatory potential of sustained cathelicidin elevation
• Acute use: Some protocols use LL-37 only during acute immune challenges rather than as an ongoing supplement
• No fasting requirement

LL-37 storage requires extra care:

• Lyophilized: Store at -20°C. LL-37 can aggregate and lose activity at higher temperatures
• Reconstituted: Refrigerate at 2–8°C, use within 14 days (shorter than many peptides due to stability concerns)
• Avoid repeated freeze-thaw cycles — aliquot into single-use portions if needed

See the peptide storage guide.