Ipamorelin: Dosage & Administration

Ipamorelin is one of the most selective growth hormone secretagogues, stimulating GH release without significantly affecting cortisol, prolactin, or appetite (unlike GHRP-6 or GHRP-2).

Protocol	Dose	Frequency	Timing
Standalone	200–300 mcg	2–3× daily	Fasted — bedtime primary
With CJC-1295 no DAC	200 mcg + 100 mcg CJC	2–3× daily	Fasted — bedtime primary

The CJC-1295/ipamorelin combination is the most common GH peptide stack in research. The GHRH analog (CJC-1295) and ghrelin receptor agonist (ipamorelin) activate two complementary pathways, producing synergistic GH release 2–3× greater than either alone.

Ipamorelin typically comes in 2mg or 5mg vials:

• 5mg vial + 2.5mL BAC water = 2mg/mL (2,000 mcg/mL) — draw 0.1mL for 200 mcg
• 2mg vial + 1mL BAC water = 2mg/mL — draw 0.1mL for 200 mcg

Use the peptide calculator for precise volumes. See the reconstitution guide for preparation.

Timing is important for maximizing ipamorelin's GH release:

• Fasting required: Administer at least 2 hours after eating. Carbohydrates and fats raise insulin and somatostatin, which suppress GH release
• Bedtime dose: The primary dose — amplifies the largest natural GH pulse that occurs during slow-wave sleep
• Post-exercise dose: Optional second dose to amplify exercise-induced GH release
• Morning dose: Optional third dose upon waking (fasted)
• Cycle length: 8–12 weeks, followed by 4–8 weeks off

Standard peptide storage:

• Lyophilized: -20°C long-term, 2–8°C for months
• Reconstituted: Refrigerate at 2–8°C, use within 28 days

See the peptide storage guide for complete guidelines.