GHRP-6: Side Effects & Safety

Part of the GHRP-6 Complete Guide

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Overall Safety Profile

GHRP-6 is one of the least selective GHRPs, producing significant appetite stimulation, cortisol elevation, and prolactin increase alongside GH release. The intense hunger is the defining side effect and the primary factor limiting its use for those who don't want appetite enhancement.

Reported Side Effects

  • Intense hunger: Onset ~20 min post-injection, lasting 30–60 min — can be uncontrollable
  • Cortisol elevation: Greater than ipamorelin
  • Prolactin elevation: Can affect reproductive function with chronic use
  • Water retention: GH-mediated
  • Tingling/numbness: Common immediately after injection
  • Transient hypoglycemia: Can lower blood glucose, followed by hunger

Important Limitations

The appetite stimulation makes GHRP-6 inappropriate for weight loss goals. Cortisol and prolactin elevations partially counteract anabolic benefits. For most GH optimization purposes, ipamorelin offers a cleaner profile. GHRP-6's niche is specifically when appetite enhancement is desired.

Potential Contraindications

  • Obesity or weight loss goals (appetite stimulation counterproductive)
  • Hyperprolactinemia
  • Cushing's syndrome
  • Diabetes (blood glucose effects)
  • Active cancer
  • Pregnancy and breastfeeding

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.