GHRP-2: Side Effects & Safety

Part of the GHRP-2 Complete Guide

Partner

Research Peptides

BioLongevity Labs15% Off
Shop Peptides at BioLongevity Labs

We may earn a commission if you purchase through this link, at no extra cost to you.

Overall Safety Profile

GHRP-2 is less selective than ipamorelin, producing notable cortisol and prolactin elevations alongside GH release. These off-target hormonal effects are the primary trade-off for its superior GH-releasing potency. Approved as a diagnostic agent in Japan, providing some safety validation for acute use.

Reported Side Effects

  • Cortisol elevation: Clinically significant — may counteract anabolic benefits with chronic use
  • Prolactin elevation: Can affect reproductive function, libido, and mood
  • Appetite increase: Moderate hunger stimulation (less than GHRP-6)
  • Water retention: GH-mediated
  • Flushing and tingling: Common immediately after injection

Important Limitations

Chronic cortisol elevation promotes visceral fat storage, muscle catabolism, and immune suppression — partially counteracting the intended anabolic effects. Prolactin elevation can cause gynecomastia, reduced libido, and mood changes. Long-term safety data from research use is absent.

Potential Contraindications

  • Hyperprolactinemia or prolactin-sensitive conditions
  • Cushing's syndrome or cortisol-related conditions
  • Active cancer
  • Pregnancy and breastfeeding

Researching peptides? We did the hard part.

Get our free Peptide Starter Kit — the 5 most researched compounds, simplified into one actionable guide.

Related Guides

Peptides for Weight Loss

Research-backed peptides studied for fat loss and metabolic support.

Peptides for Muscle Growth

Compounds researched for lean mass, recovery, and performance.

Peptides for Healing

Peptides studied for tissue repair, injury recovery, and regeneration.

How to Reconstitute Peptides

Step-by-step guide to safely mixing lyophilized peptides with BAC water.

How to Inject Peptides

Subcutaneous injection technique, site rotation, and sterile handling.

Peptide Reconstitution Calculator

Calculate exact BAC water volumes and dosing for any peptide vial.

PI

Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.