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Dihexa: Dosage & Administration

Part of the Dihexa Complete Guide

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Dihexa Dosage Protocols

Dihexa dosing in research requires extreme caution due to its extraordinary potency — it has been reported to be up to 10 million times more potent than BDNF in promoting synaptogenesis.

RouteDoseFrequencyDuration
Oral5–20 mgOnce daily2–4 weeks
Subcutaneous1–5 mgOnce daily2–4 weeks

Dihexa is notable among peptides for having oral bioavailability, making it accessible without injection. The low dose range reflects its extreme potency as a hepatocyte growth factor (HGF) pathway modulator. Research on dihexa is preliminary, and dosing guidelines are based on limited animal and early human data.

Reconstitution & Preparation

Dihexa is available in both capsule (oral) and lyophilized (injectable) forms:

  • Oral: Pre-dosed capsules — no reconstitution needed
  • Injectable: Reconstitute with bacteriostatic water following standard procedures. Due to very low doses, precise concentration calculation is essential

For injectable preparation, use the peptide calculator for exact volumes. See the reconstitution guide for general preparation.

Timing & Cycle Length

Dihexa timing considerations:

  • Time of day: Morning administration is commonly preferred for its cognitive-enhancing applications
  • Cycle length: Short cycles of 2–4 weeks are typical, given the limited long-term safety data
  • No fasting requirement for oral administration
  • Caution: The extreme potency of dihexa warrants conservative dosing and cycle length

Storage

Dihexa storage:

  • Capsules: Store in a cool, dry place. Refrigeration extends shelf life
  • Lyophilized: -20°C long-term, 2–8°C for months
  • Reconstituted: Refrigerate at 2–8°C, use within 28 days

See the peptide storage guide.

Frequently Asked Questions

References

  1. McCoy AT, et al.. Evaluation of metabolically stabilized angiotensin IV analogs as procognitive/antidementia agents. Journal of Pharmacology and Experimental Therapeutics, 2013.
  2. Benoist CC, et al.. Dihexa-facilitated rescue of cognitive deficits in aged rats. Frontiers in Aging Neuroscience, 2014.

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.