Cagrilintide: Side Effects & Safety

Part of the Cagrilintide Complete Guide

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Overall Safety Profile

Cagrilintide's safety profile in clinical trials is similar to other incretin-based therapies, with gastrointestinal effects being most common. Safety data is still accumulating as Phase 3 trials are ongoing.

Reported Side Effects

  • Nausea: Most common, generally mild to moderate, decreasing over time
  • Vomiting and diarrhea: Common GI effects
  • Injection site reactions: Mild and transient
  • Decreased appetite: Therapeutic effect but can be excessive

Important Limitations

Cagrilintide is still in Phase 3 clinical trials. Long-term safety data (>1 year) is limited. The effects of chronic amylin receptor activation on bone density, pancreatic function, and other organ systems require further characterization.

Potential Contraindications

  • Known hypersensitivity to amylin analogs
  • Gastroparesis or severe GI motility disorders
  • Pregnancy and breastfeeding (no safety data)

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.