BPC-157: Benefits & Research

Part of the BPC-157 Complete Guide

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Musculoskeletal Healing

  • Tendon healing: 2–3× faster Achilles tendon healing in rats with better collagen organization and tensile strength
  • Ligament repair: Accelerated MCL healing with improved biomechanical properties
  • Muscle injury: Faster recovery from crush injuries and lacerations with reduced fibrosis
  • Bone healing: Accelerated fracture callus formation

BPC-157 promotes healing primarily through VEGF-driven angiogenesis (new blood vessel formation), growth factor upregulation, and enhanced fibroblast proliferation at injury sites.

Gastrointestinal Protection

  • Protection against NSAID-induced gastric ulcers and lesions
  • Healing of IBD lesions in colitis models
  • Protection against alcohol-induced gastric damage
  • Healing of esophageal, gastric, and intestinal fistulas

BPC-157 and KPV are often discussed together for gut health — BPC-157 promotes tissue repair while KPV reduces inflammatory signaling.

Neuroprotective Effects

BPC-157 has shown neuroprotective effects in models of traumatic brain injury, peripheral nerve transection, and neurotoxin exposure. It counteracted dopaminergic toxin effects and promoted peripheral nerve regeneration. For related healing peptides, see the peptides for healing guide.

References

  1. Staresinic M, et al.. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon. Journal of Orthopaedic Research, 2003.
  2. Sikiric P, et al.. Brain-gut axis and pentadecapeptide BPC 157. Current Neuropharmacology, 2016.

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Peptides Insider Editorial Team

Our content is reviewed for accuracy and grounded in peer-reviewed research where available. We do not provide medical advice. Always consult a qualified healthcare professional.